AMR occurs when germs like bacteria, viruses and fungi evolve in ways that make the medicines used to treat them stop working. These germs can then cause resistant infections that can be difficult and sometimes impossible to treat.1

1.27M

deaths in 2019

AMR is a Growing Threat

In 2022, the Lancet Medical Journal published a study asserting that antibiotic-resistant infections were the direct cause of 1.27 million deaths and played some role in 4.95 million deaths in 2019.

This puts bacterial AMR as the third leading cause of death in 2019, after heart disease and stroke. If antibiotics and antifungals lose their effectiveness, then we lose the ability to treat infections and control these public health threats. But the challenge goes beyond treating infections – much of modern medical practice relies on preventive use of antibiotics for common surgeries and treatments. Increasing resistance means riskier procedures we take for granted now.2

By 2050, it is estimated AMR will cause more deaths than cancer. 3

The Consequences of AMR

  • Common infections, such as wound infections, urinary tract infections and pneumonia will increasingly be associated with severe complications and increased risk of death.
  • Many childhood and maternal infections such as pneumonia and childbed fever could become fatal again – as they still are in many countries with limited access to antibiotics.
  • Common surgeries like c-sections and hip replacements become much riskier. Non-vital surgeries would become difficult to justify due to the risk of resistant infection.
  • As chemotherapy causes immune suppression, cancer treatment would become substantially riskier. Without effective antimicrobials, even uncomplicated infections could become fatal.
  • With few options to treat potential infections, therapies that require immune suppression, such as organ transplants, could be untenable.4

Antibiotics and Cancer

Antibiotics are essential for effective treatment of several medical conditions, including cancer. According to the ReAct Group, effective cancer treatment has the highest risk of being impacted by anti-microbial resistance. AMR may not only affect the possibilities of treating cancer patients’ infections, but also what kind of cancer treatment can be offered.​ The risks of contracting resistant surgical site infections may outweigh benefits of surgery if infection treatment options are limited by AMR. There are also risks of untreatable bloodstream infections that must be balanced against the benefits of chemotherapy. Severe infections and sepsis are among the most frequent reasons cancer patients are admitted to intensive care units. It has been estimated close to one in ten cancer deaths is due to severe sepsis – not the cancer itself. One study found that 70% of cancer patients who initially received ineffective antibiotic treatment for bloodstream infections died within a month, compared to less than 20% of those who received appropriate antibiotics.

Tools to Combat AMR

Successfully fighting AMR requires a multipronged approach. Some tools that would help fight AMR include:

Proactive Infection Prevention

Improved hospital-based infection control, hygiene, and sanitation can prevent infections and reduce the use of antibiotics. Vaccination can reduce the inappropriate and overuse of antibiotics.

Stewardship

Antibiotics are too often used inappropriately, such as for treating viral infections. Better understanding is needed among healthcare providers and patients on the proper use of antimicrobials to ensure they are used only when relevant, at the appropriate dose, and for the right amount of time

Collaboration

Whether it is developing new antibiotics or improving awareness, stakeholders across the board must work together with no silos to find new ways to address these unmet needs. Governments must work together on AMR through surveillance networks, data sharing, and ensuring global supply chains. Each one will help provide broad and equitable access to diagnostics and medicines.

Access

Preserving the availability of a wide range of antibiotics is critical for ensuring doctors and patients have access to ideal treatment and avoid the suboptimal use of antibiotics. However, the sustained availability of some antibiotics is at risk due to unsustainable market dynamics. Many antibiotics are decades old and have been available as generics for years. In some cases, prices have dropped so low for these treatments that it is no longer viable for their manufacturers to continue making or selling them. With fewer companies making these drugs, there is a greater risk of shortages in the event of supply disruptions. To ensure continued access to a wide range of antimicrobials, we encourage policymakers and payers to foster a sustainable market for antibiotics, including older products.

Viatris' Commitment

At Viatris, we recognize the responsibility that comes with our role as a leader in this space. We have 90+ antibiotics in our global portfolio and take pride in our contribution to facilitating access to antibiotics.

As a founding member of the AMR Industry Alliance, Viatris is committed to partnering across industry to collectively advance initiatives addressing AMR. These efforts have led to progress in advancing science-based approaches to help manage the impact of anti-microbial manufacturing, develop initiatives to enhance antibiotic stewardship and improve sustainable access to appropriate antibiotics. The AMR Industry Alliance Progress Report showcases the work of Viatris, and other Alliance member companies committed to tackling AMR, together.

In the Access to Medicine Foundation’s AMR Benchmark, Viatris was recognized as one of the top three generics manufacturers for championing appropriate access, stewardship, and responsible manufacturing. We were commended for our transparency in reporting on our environmental risk management strategy for manufacturing sites and for meeting discharge targets at our sites. The report also recognized Viatris’ strategies for expanding access, including making treatment for drug-resistant TB available in more countries than ever and ensuring a continuous supply of relevant products. We were also acknowledged for our AMR education programs for healthcare providers.

1. https://www.cdc.gov/drugresistance/about.html
2. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)02724-0/fulltext
3. The Review on Antimicrobial Resistance – White Paper, 2014
4. ReAct Group